| Evolent Pathways | Febrile Neutropenic Risk | Emetogenic Risk | References | ||
|---|---|---|---|---|---|
| PURE SEMINOMA | |||||
Initial (Stage I-III) |
carboplatin *Stage 1A, 1B* |
Low | High |
|
|
etoposide and cisplatin (EP) |
Intermediate | High |
|
||
bleomycin, etoposide and cisplatin (BEP) |
Intermediate | High |
|
||
Subsequent Therapy |
VeIP (vinblastine, ifosfamide and cisplatin) |
High | High |
|
|
TIP (paclitaxel, ifosfamide and cisplatin) |
High | High |
|
||
gemcitabine and oxaliplatin |
Low | Moderate | |||
gemcitabine and paclitaxel |
Low | Low |
|
||
etoposide (oral) |
Low | High |
|
||
Best Supportive Care or Clinical Trial |
|
||||
| NON-SEMINOMA | |||||
Initial (Stage I-III) |
etoposide and cisplatin (EP) |
Intermediate | High | ||
bleomycin, etoposide and cisplatin (BEP) |
Intermediate | High |
|
||
etoposide, ifosfamide and cisplatin (VIP) |
High | High |
|
||
Brain Metastases (+/- RT, +/- surgery) |
bleomycin, etoposide and cisplatin (BEP) |
Intermediate | High |
|
|
etoposide, ifosfamide and cisplatin (VIP) |
High | High |
|
||
Subsequent Therapy |
etoposide and cisplatin (EP) |
Intermediate | High |
|
|
VeIP (vinblastine, ifosfamide and cisplatin) |
High | High |
|
||
TIP (paclitaxel, ifosfamide and cisplatin)
|
High | High |
|
||
Best Supportive Care or Clinical Trial |
|
||||
Initial (Stage I-III)
carboplatin *Stage 1A, 1B*
etoposide and cisplatin (EP)
bleomycin, etoposide and cisplatin (BEP)
Subsequent Therapy
VeIP (vinblastine, ifosfamide and cisplatin)
TIP (paclitaxel, ifosfamide and cisplatin)
gemcitabine and oxaliplatin
gemcitabine and paclitaxel
etoposide (oral)
Best Supportive Care or Clinical Trial
Initial (Stage I-III)
etoposide and cisplatin (EP)
bleomycin, etoposide and cisplatin (BEP)
etoposide, ifosfamide and cisplatin (VIP)
Brain Metastases (+/- RT, +/- surgery)
bleomycin, etoposide and cisplatin (BEP)
etoposide, ifosfamide and cisplatin (VIP)
Subsequent Therapy
etoposide and cisplatin (EP)
VeIP (vinblastine, ifosfamide and cisplatin)
TIP (paclitaxel, ifosfamide and cisplatin)
Best Supportive Care or Clinical Trial