DEFINITION OF PROPHYLAXIS

Primary Prophylaxis for Chemotherapy Induced Febrile Neutropenia defined as:

• High risk regimens with > 20% risk of Febrile Neutropenia (FN) (neutropenia with fever)
• Dose - dense chemotherapy
• Intermediate risk regimens with 10-20% risk of FN with one additional risk factor. The risk factors are: Prior chemotherapy or radiation therapy; persistent neutropenia; bone marrow involvement by tumor; recent surgery and/or open wounds; liver dysfunction (bili > 2.0) renal dysfunction (crcl < 50); age > 65 years receiving full chemotherapy dose intensity
• Secondary Prophylaxis: prior history of febrile neutropenia with the current chemotherapy regimen
• For metastatic disease, recommend cycle delays and/or dose reduction