| Evolent Pathways | Febrile Neutropenic Risk | Emetogenic Risk | References | ||
|---|---|---|---|---|---|
| INDUCTION | |||||
cytarabine and daunorubicin |
High | Moderate |
|
||
cytarabine and idarubicin |
High | Moderate |
|
||
daunorubicin and cytarabine, liposome *for pts who are suitable for intensive therapy and age ≥60 years; therapy related AML or AML from prior MDS* |
High | Moderate |
|
||
azacitidine or decitabine and venetoclax *for patients that are not suitable for intensive therapy, e.g. unfit elderly patients* |
High | Moderate |
|
||
cytarabine, daunorubicin and midostaurin *FLT3 mutation* |
High | Moderate |
|
||
cytarabine, idarubicin and midostaurin *FLT3 mutation* |
High | Moderate |
|
||
ivosidenib and azacitidine *IDH1 mutation positive* |
Low | Moderate |
|
||
quizartinib and cytarabine and daunorubicin or idarubicin *FLT3-ITD mutation* |
High | Moderate |
|
||
| CONSOLIDATION | |||||
cytarabine and daunorubicin |
High | Moderate |
|
||
cytarabine and idarubicin |
Intermediate | Moderate |
|
||
daunorubicin and cytarabine, liposome *for pts who are suitable for intensive therapy and age ≥60 years; therapy related AML or AML from prior MDS* |
High | Moderate |
|
||
HiDAC (high dose cytarabine) |
Low | Low |
|
||
cytarabine and midostaurin *FLT3 mutation* |
High | Moderate |
|
||
quizartinib and cytarabine *FLT3-ITD mutation* |
High | Moderate |
|
||
| MAINTENANCE | |||||
quizartinib *FLT3-ITD mutation* who previously received quizartinib and with no allogeneic HCT planned |
High | Moderate |
|
||
| RELAPSED/REFRACTORY | |||||
cytarabine and daunorubicin |
High | Moderate |
|
||
cytarabine and idarubicin |
High | Moderate |
|
||
fludarabine and cytarabine |
High | Moderate |
|
||
fludarabine, cytarabine and idarubicin (FLAG-IDA) |
High | Moderate |
|
||
ivosidenib *IDH-1 mutation positive* |
Low | Moderate |
|
||
enasidenib *IDH-2 mutation positive* |
Low | Moderate |
|
||
gilteritinib *FLT3 mutation positive* |
Low | Moderate |
|
||
Best Supportive Care or Clinical Trial |
Not Applicable | Not applicable |
|
||
cytarabine and daunorubicin
cytarabine and idarubicin
daunorubicin and cytarabine, liposome *for pts who are suitable for intensive therapy and age ≥60 years; therapy related AML or AML from prior MDS*
azacitidine or decitabine and venetoclax *for patients that are not suitable for intensive therapy, e.g. unfit elderly patients*
cytarabine, daunorubicin and midostaurin *FLT3 mutation*
cytarabine, idarubicin and midostaurin *FLT3 mutation*
ivosidenib and azacitidine *IDH1 mutation positive*
quizartinib and cytarabine and daunorubicin or idarubicin *FLT3-ITD mutation*
cytarabine and daunorubicin
cytarabine and idarubicin
daunorubicin and cytarabine, liposome *for pts who are suitable for intensive therapy and age ≥60 years; therapy related AML or AML from prior MDS*
HiDAC (high dose cytarabine)
cytarabine and midostaurin *FLT3 mutation*
quizartinib and cytarabine *FLT3-ITD mutation*
quizartinib *FLT3-ITD mutation* who previously received quizartinib and with no allogeneic HCT planned
cytarabine and daunorubicin
cytarabine and idarubicin
fludarabine and cytarabine
fludarabine, cytarabine and idarubicin (FLAG-IDA)
ivosidenib *IDH-1 mutation positive*
enasidenib *IDH-2 mutation positive*
gilteritinib *FLT3 mutation positive*
Best Supportive Care or Clinical Trial
| Regimen | Alternative | References | |||
|---|---|---|---|---|---|
| LOW VALUE REGIMENS (NON-PATHWAY) WITH SUPERIOR ALTERNATIVES | |||||
Induction |
fludarabine and HiDAC and idarubicin and G-CSF and gemtuzumab ozogamicin |
Alternative: cytarabine and daunorubicin/idarubicin |
|||
Induction |
daunorubicin and cytarabine, liposome |
Alternative: cytarabine and daunorubicin/idarubicin |
|||
Induction/consolidation |
gemtuzumab ozogamicin |
Alternative: cytarabine and daunorubicin/idarubicin |
|||
Induction
fludarabine and HiDAC and idarubicin and G-CSF and gemtuzumab ozogamicin
Induction
daunorubicin and cytarabine, liposome
Induction/consolidation
gemtuzumab ozogamicin